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  • SPOTLIGHTS
  • Nankai’s Scientific Research Team Successfully Transformed Granulosa Cells to?Oocytes That Produce Healthy Mice

    Prof. Lin Liu’s team from Nankai University’s College of Life Sciences and Stat Key Laboratory of Medical Chemical Biology successfully reprogrammed granulosa cells into inducible pluripotent stem cells with germline metastasis ability by completely chemical programming. The stem cells then differentiate into oocytes that produce healthy mice through normal fertilization. This research is carried out for the first time in the world and opens up new ideas for research such as maintaining fertility and regulating body endocrine. This method of chemical reprogramming can effectively avoid ethical issues and reduce safety risks. Recently, a paper introducing the results was published in the international academic journal “Cell Reports”, and the top international journal “Cell” recommended this finding as a headline article.


    Figure: Granulosa cells are reprogrammed into inducible pluripotent stem cells with germline metastasis ability by completely chemical programming. The stem cells then differentiate into oocytes that produce healthy mice through normal fertilization.

    If a sufficient amount of oocytes can be obtained from outside the body and added to the ovaries in the body, it will be of great value for restoring reproductive capacity and clinically treating diseases such as reproductive aging. This is also a scientific challenge for biologists from all over the world. Prof. Lin Liu’s team solved the problem by chemical reprogramming.


    Granulosa cells are reprogrammed into inducible pluripotent stem cells with germline metastasis ability by completely chemical programming. The stem cells then differentiate into oocytes that produce healthy mice through normal fertilization.

    With this assumption, after times of experiments, Prof. Liu’s team finally prepared a small molecule culture solution containing sodium crotonic acid and other chemicals to treat cells. This approach can effectively turn granulosa cells into inducible pluripotent stem cells, and the later are proved to have stable genome, gradually extended telomeres, and higher quality.

    The research (Telomere Regeneration and Ovarian Function Reconstruction) is supported by the National Natural Science Foundation of China and China National Key R&D Program.

    Link to the paper: https://doi.org/10.1016/j.celrep.2019.11.080

     Translated by Yuchen Shi,Edited by Davide Francolino and JianjingYun


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